Amantadine-induced lipidosis. A cytological and physicochemical study
Identifieur interne : 003323 ( Main/Exploration ); précédent : 003322; suivant : 003324Amantadine-induced lipidosis. A cytological and physicochemical study
Auteurs : J. Burmester [Allemagne] ; R. Hanpft [Allemagne] ; Kornelia Kröplin [Allemagne] ; Renate Lüllmann-Rauch [Allemagne] ; M. Patten [Allemagne]Source :
- Toxicology [ 0300-483X ] ; 1987.
English descriptors
- Teeft :
- Abnormal inclusions, Adrenal gland, Amantadine, Amantadine molecule, Amphiphilic, Amphiphilic cationic drugs, Animal experiments, Area postrema, Biochem, Blood smears, Capillary endothelia, Cationic, Cationic amphiphilic drug inhibition, Cationic amphiphilic drugs, Cell culture experiments, Cell cultures, Chlorphentermine, Cultured cells, Cultured macrophages, Cytoplasmic inclusions, Dense inclusions, Dppc, Drug concentration, Drug molecules, Drug treatment, Duct, Effective intercalation, Electron microscopy, Generalized lipidosis, Inclusion, Inherent efficacy, Inner medulla, Intact animals, Intercalated cells, Interstitial cells, Kidney cells, Lamellated, Lamellated inclusion bodies, Lamellated inclusions, Lipid, Lipidosis, Lipidosis induction, Lymph node, Lymph nodes, Lymphocyte, Lysosomal, Lysosomal phospholipases, Lysosomal storage disorders, Lysosome, Macrophage, Medulla, Node, Other drugs, Outer medulla, Peritoneal macrophages, Petri dishes, Pharmacol, Phase transition, Phase transition behaviour, Phase transition temperature, Phosphatidylserine monolayers, Phospholipid, Pigment epithelium, Polar lipids, Present experiments, Present study, Publishers ireland, Reference compound, Semithin section, Strong interaction, Structural features, Thin limbs, Trace amounts, Transition temperature, Ultrastructural, Vivo conditions.
Abstract
Abstract: The purpose of this study was to test whether or not the antiviral drug amantadine induces the structural features of lipidosis in intact animals (rats) and cultured cells, and to investigate the interactions between amantadine and phospholipids. Chlorphentermine was used as reference compound. When subchronically fed to rats at a daily dosage of approximately 180 mg/kg, amantadine induced ultrastructural symptoms of generalized lipidosis, the degree of which was, however, by far less marked than that previously reported for chlorphentermine. This was paralleled by the findings on cell cultures (rat peritoneal macrophages), where the lipidosis-inducing potency of amantadine was approximately 10-fold lower than that of chlorphentermine. As to drug-phospholipid interactions, amantadine had less marked effects than chlorphentermine upon the phase transition characteristics of phosphatidylcholine and phosphatidic acid; furthermore, amantadine was approximately 10-fold less potent than chlorphentermine in displacing Ca from phosphatidylserine monolayers. The present study has revealed a parallel between the comparatively low lipidosis-inducing efficacy inherent to amantadine and the comparatively low tendency to interact with phospholipids. It is suggested that the cage-like structure of the amantadine molecule hinders an effective intercalation of the drug into phospholipid aggregates, and that this is an essential factor responsible for the low inherent efficacy of amantadine with respect to lipidosis induction.
Url:
DOI: 10.1016/0300-483X(87)90045-X
Affiliations:
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Hanpft</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department of Pharmacology, University of Kiel</wicri:regionArea><wicri:noRegion>University of Kiel</wicri:noRegion><wicri:noRegion>University of Kiel</wicri:noRegion></affiliation></author><author><name sortKey="Kroplin, Kornelia" sort="Kroplin, Kornelia" uniqKey="Kroplin K" first="Kornelia" last="Kröplin">Kornelia Kröplin</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department of Anatomy, University of Kiel</wicri:regionArea><wicri:noRegion>University of Kiel</wicri:noRegion><wicri:noRegion>University of Kiel</wicri:noRegion></affiliation></author><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Address all correspondence to: Professor Dr. R. Lüllman-Rauch, Department of Anatomy, University of Kiel, Olshausenstrasse 40, D-2300 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department of Anatomy, University of Kiel</wicri:regionArea><wicri:noRegion>University of Kiel</wicri:noRegion><wicri:noRegion>University of Kiel</wicri:noRegion></affiliation></author><author><name sortKey="Patten, M" sort="Patten, M" uniqKey="Patten M" first="M." last="Patten">M. Patten</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department of Pharmacology, University of Kiel</wicri:regionArea><wicri:noRegion>University of Kiel</wicri:noRegion><wicri:noRegion>University of Kiel</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology</title><title level="j" type="abbrev">TOX</title><idno type="ISSN">0300-483X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">44</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="45">45</biblScope><biblScope unit="page" to="59">59</biblScope></imprint><idno type="ISSN">0300-483X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-483X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormal inclusions</term><term>Adrenal gland</term><term>Amantadine</term><term>Amantadine molecule</term><term>Amphiphilic</term><term>Amphiphilic cationic drugs</term><term>Animal experiments</term><term>Area postrema</term><term>Biochem</term><term>Blood smears</term><term>Capillary endothelia</term><term>Cationic</term><term>Cationic amphiphilic drug inhibition</term><term>Cationic amphiphilic drugs</term><term>Cell culture experiments</term><term>Cell cultures</term><term>Chlorphentermine</term><term>Cultured cells</term><term>Cultured macrophages</term><term>Cytoplasmic inclusions</term><term>Dense inclusions</term><term>Dppc</term><term>Drug concentration</term><term>Drug molecules</term><term>Drug treatment</term><term>Duct</term><term>Effective intercalation</term><term>Electron microscopy</term><term>Generalized lipidosis</term><term>Inclusion</term><term>Inherent efficacy</term><term>Inner medulla</term><term>Intact animals</term><term>Intercalated cells</term><term>Interstitial cells</term><term>Kidney cells</term><term>Lamellated</term><term>Lamellated inclusion bodies</term><term>Lamellated inclusions</term><term>Lipid</term><term>Lipidosis</term><term>Lipidosis induction</term><term>Lymph node</term><term>Lymph nodes</term><term>Lymphocyte</term><term>Lysosomal</term><term>Lysosomal phospholipases</term><term>Lysosomal storage disorders</term><term>Lysosome</term><term>Macrophage</term><term>Medulla</term><term>Node</term><term>Other drugs</term><term>Outer medulla</term><term>Peritoneal macrophages</term><term>Petri dishes</term><term>Pharmacol</term><term>Phase transition</term><term>Phase transition behaviour</term><term>Phase transition temperature</term><term>Phosphatidylserine monolayers</term><term>Phospholipid</term><term>Pigment epithelium</term><term>Polar lipids</term><term>Present experiments</term><term>Present study</term><term>Publishers ireland</term><term>Reference compound</term><term>Semithin section</term><term>Strong interaction</term><term>Structural features</term><term>Thin limbs</term><term>Trace amounts</term><term>Transition temperature</term><term>Ultrastructural</term><term>Vivo conditions</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The purpose of this study was to test whether or not the antiviral drug amantadine induces the structural features of lipidosis in intact animals (rats) and cultured cells, and to investigate the interactions between amantadine and phospholipids. Chlorphentermine was used as reference compound. When subchronically fed to rats at a daily dosage of approximately 180 mg/kg, amantadine induced ultrastructural symptoms of generalized lipidosis, the degree of which was, however, by far less marked than that previously reported for chlorphentermine. This was paralleled by the findings on cell cultures (rat peritoneal macrophages), where the lipidosis-inducing potency of amantadine was approximately 10-fold lower than that of chlorphentermine. As to drug-phospholipid interactions, amantadine had less marked effects than chlorphentermine upon the phase transition characteristics of phosphatidylcholine and phosphatidic acid; furthermore, amantadine was approximately 10-fold less potent than chlorphentermine in displacing Ca from phosphatidylserine monolayers. The present study has revealed a parallel between the comparatively low lipidosis-inducing efficacy inherent to amantadine and the comparatively low tendency to interact with phospholipids. It is suggested that the cage-like structure of the amantadine molecule hinders an effective intercalation of the drug into phospholipid aggregates, and that this is an essential factor responsible for the low inherent efficacy of amantadine with respect to lipidosis induction.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Burmester, J" sort="Burmester, J" uniqKey="Burmester J" first="J." last="Burmester">J. Burmester</name></noRegion><name sortKey="Hanpft, R" sort="Hanpft, R" uniqKey="Hanpft R" first="R." last="Hanpft">R. Hanpft</name><name sortKey="Kroplin, Kornelia" sort="Kroplin, Kornelia" uniqKey="Kroplin K" first="Kornelia" last="Kröplin">Kornelia Kröplin</name><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><name sortKey="Patten, M" sort="Patten, M" uniqKey="Patten M" first="M." last="Patten">M. Patten</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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